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University of Michigan Innovation Partnerships
University of Michigan Innovation Partnerships

Clinical Drug Pipeline

Therapeutic Company Phase I Phase I/II Phase II Phase III Marketed Indication FDA Approval Year 
Auryxia (ferric citrate) Akebia Therapeutics     Iron-deficient anemia for patints with Chronic Kidney Disease not on dialysis, Hyperphosphatemia for CKD on dialysis 2014 
Alrizomadlin (APG-115) Ascentage Pharma Hematologic Malignancies; Acute Myelogenous Leukemia, Myelodysplastic Syndrome Malignant Salivary Gland Cancer; Advanced Liposarcoma and Advanced Solid Tumors Unresectable or Metastatic Melanoma or Advanced Solid Tumors; T-Prolymphocytic Leukemia   
Pelcitoclax (APG-1252) Ascentage Pharma EGFR-positive Non-Small Cell Lung Cancer; Neuroendocrine tumors Small Cell Lung Cancer; Myelofibrosis     
APG-1387 Ascentage Pharma Advanced Solid Tumors and Hematologic Malignancies; Pancreatic Ductal Adenocarcinoma Advanced Solid Tumors Hepatitis B  
APG-2449 Ascentage Pharma Advanced Solid Tumors      
Lisaftoclax (APG-2575) Ascentage Pharma Breast Cancer; Waldenstrom Macroglobulinemia; Chronic Lymphocytic Leukemia; Small Lymphocytic Leukemia; Non-Hodgkin Lymphoma Relapsed or refractory AML Chronic Lymphocytic Leukemia; Small Lymphocytic Leukemia; T-Prolymphocytic Leukemia    
ALXN1840 (formerly WTX101) AstraZeneca plc    Wilson Disease   
ZYBK2 Cadilla Healthcare Rheumatoid Arthritis      
CLR 131 Cellectar Biosciences Pediatric Solid Tumors and Lymphomas  Multiple Myeloma, Chronic Lymphocytic Leukemia, and lymphomas    
Reparixin Dompe Farmaceutici    Fatigue; Locally Advanced or Metastatic Breast Cancer   
Cerdelga eliglustat Genzyme Corp (part of Sanofi)    Gaucher’s Disease Type III Gaucher’s Disease Type I 2014 
KO-539 Kura Oncology  Acute Myelogenous Leukemia     
FluMist Quadrivalent MedImmune (part of AstraZeneca)     Influenza Vaccine 2012 
Xevinapant (formerly Debio 1143) Merck KGaA  Solid Tumors  Head & Neck Cancer   
ONL1204 ONL Therapeutics Rhegmatogenous Retinal Detachment – Macula Off; Geographic Atrophy; Open Angle Glaucoma      
P-188 NF Phrixus Pharmaceuticals   Duchenne Muscular Dystrophy    
SGT-001 Solid Biosciences  Duchenne Muscular Dystrophy     
Livtencity (formerly called TAK-620, SHP620, maribavir, GW1263, VP 41263) Takeda Pharmaceuticals     Cytomegalovirus Infection in Transplant Recipients 2021 
TAK-755 Takeda Pharmaceuticals Sickle Cell Disease   Congenital Thrombotic Thrombocytopenic Purpura; Acquired Thrombotic Thrombocytopenic Purpura